"Effect of local application of simvastatin in bone regeneration of peri-apical defects-a clinico-radiographic study

• Main Authors: Sweety Gupta (Author), Promila Verma (Author), Aseem Prakash Tikku (Author), Anil Chandra (Author), Rakesh Kumar Yadav (Author), Ramesh Bharti (Author), Rhythm Bains (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2212-4268; 10.1016/j.jobcr.2020.08.014
• Keywords: CBCT-PAI; Hydroxyapatite; Bone regeneration; Platelet rich fibrin; Simvastatin; Dentistry; RK1-715
• Source: Journal of Oral Biology and Craniofacial Research, Vol 10, Iss 4, Pp 583-591 (2020)

Objective: The present study evaluates and compares the effectiveness of Simvastatin (SIM), Hydroxyapatite (HA), and platelet-rich fibrin (PRF) in bone regeneration of periapical defects. Material& method: Thirty-nine patients were selected and randomized into three groups, Group 1: HA (n = 13), Group 2: PRF (n = 13), Group 3: SIM (n = 13). After completion of RCT and apicoectomy, the grafts were placed locally in the defect and sutured. Results: At the end of twelve months, postoperative symptoms and radiographic analysis assessed the outcome of the treatment Conclusion: Intragroup analysis of CBCT- Periapical Index (PAI) scores at 6th and 12th month revealed a significant change in the SIM group (p = 0.018 and 0.001 respectively), compared to PRF (p = 0.026 and 0.001 respectively) and HA (p = 0.053 and 0.039 respectively). Intergroup analysis of change in the level of CBCT-PAI score was highly significant (p = 0.003).SIM caused a more considerable change in the level of CBCT-PAI score compared to other groups, thereby indicating a faster rate of bone regeneration.