A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments

• Glavni autori: Xiao-Hua Li (Autor), Wei-Wei Pang (Autor), Yue Zhang (Autor), Dan-Yang Liu (Autor), Qiao-Rong Yi (Autor), Ning Wang (Autor), Fu-Rong Zhang (Autor), Yun Deng (Autor), Xiang-Ding Chen (Autor), Jonathan Greenbaum (Autor), Hong-Mei Xiao (Autor), Hong-Wen Deng (Autor), Li-Jun Tan (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background: Lipid pathways have been implicated in the pathogenesis of osteoporosis (OP). Lipid-lowering drugs may be used to prevent and treat OP. However, the causal interpretation of results from traditional observational designs is controversial by confounding. We aimed to investigate the causal...