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Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

The β-catenin and MDM2 oncoproteins are overexpressed and constitutively activated in human pancreatic cancer and contribute to its initiation, progression, and metastasis. The Wnt/β-catenin signaling pathway strongly interacts with the MDM2-p53 signaling pathway, accelerating the tumorigenesis and...

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Bibliographic Details
Main Authors:	Jiang-Jiang Qin (Author), Wei Wang (Author), Xin Li (Author), Hemantkumar Deokar (Author), John K. Buolamwini (Author), Ruiwen Zhang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2018-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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