The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
Abstract The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF metho...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
SpringerOpen,
2021-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method. |
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| Item Description: | 10.1186/s41181-021-00141-0 2365-421X |