The toxicokinetic profile of Dex40-GTMAC3 - a novel polysaccharide candidate for reversal of unfractionated heparin.

• Main Authors: Emilia eSokolowska (Author), Bartlomiej eKalaska (Author), Kamil eKaminski (Author), Alicja eLewandowska (Author), Agnieszka eBlazejczyk (Author), Joanna eWietrzyk (Author), Irena eKasacka (Author), Krzysztof eSzczubialka (Author), Dariusz ePawlak (Author), Maria eNowakowska (Author), Andrzej eMogielnicki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Though protamine sulfate is the only approved antidote of unfractionated heparin (UFH), yet may produce life threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions. We have described 40 kDa dextrans (Dex40) substituted with glycidyltrimet...