Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled release

• Main Authors: Sara Baldassari (Author), Paola Cirrincione (Author), Giorgia Ailuno (Author), Giuliana Drava (Author), Silvia Arpicco (Author), Gabriele Caviglioli (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polycarbophil (POL), a polyacrylic acid cross-linked with divinyl glycol, is widely used in semisolid and solid dosage forms. When undergoing a thermal treatment in the range 120-160 °C, POL shows interesting morphological modifications, related to changes in physical properties, such as swelling of...