Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases

• Main Authors: Huakang Zhou (Author), Dilaware Khan (Author), Sajid Muhammad Hussain (Author), Norbert Gerdes (Author), Carsten Hagenbeck (Author), Majeed Rana (Author), Jan Frederick Cornelius (Author), Sajjad Muhammad (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Smoking, alcohol abuse, and hypertension are - among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resulting in cellular senescence and senescence-associated secretory phenot...