Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

• Main Authors: David Malinak (Author), Rafael Dolezal (Author), Vendula Hepnarova (Author), Miroslava Hozova (Author), Rudolf Andrys (Author), Petr Bzonek (Author), Veronika Racakova (Author), Jan Korabecny (Author), Lukas Gorecki (Author), Eva Mezeiova (Author), Miroslav Psotka (Author), Daniel Jun (Author), Kamil Kuca (Author), Kamil Musilek (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) inhibition, when the majority of novel compounds...