Anti-cancer natural products isolated from chinese medicinal herbs

• Main Authors: Wu Guosheng (Author), Chen Meiwan (Author), Li Yingbo (Author), Huang Mingqing (Author), Lu Jinjian (Author), Tan Wen (Author), Gong Jian (Author), Zhong Zhangfeng (Author), Xu Zengtao (Author), Dang Yuanye (Author), Guo Jiajie (Author), Chen Xiuping (Author), Wang Yitao (Author)
• Format: Book
• Published: BMC, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both <it>in vitro </it>and <it>in vivo</it>. This article summarizes recent advances in <it>in vitro </it>and <it>in </it><it>vivo </it>research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin), alkaloids (berberine), terpenes (artemisinin, β-elemene, oridonin, triptolide, and ursolic acid), quinones (shikonin and emodin) and saponins (ginsenoside Rg₃), which are isolated from Chinese medicinal herbs. In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed.</p>

Item Description

10.1186/1749-8546-6-27
1749-8546