Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo

• Main Authors: Yanbin Dong (Author), Jamie Carty (Author), Nitsan Goldstein (Author), Zhenyan He (Author), Eunsang Hwang (Author), Dominic Chau (Author), Briana Wallace (Author), Anita Kabahizi (Author), Linh Lieu (Author), Yunqian Peng (Author), Yong Gao (Author), Ling Hu (Author), J. Nicholas Betley (Author), Kevin W. Williams (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs), like liraglutide and semaglutide, are viable treatments for diabetes and obesity. Liraglutide directly activates hypothalamic proopiomelanocortin (POMC) neurons while indirectly inhibiting Neuropeptide Y/Agouti-related pept...