S1P/S1PR1 signaling is involved in the development of nociceptive pain

• Main Authors: Daosong Dong (Author), Xue Yu (Author), Xueshu Tao (Author), Qian Wang (Author), Lin Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundPain is a complex perception involving unpleasant somatosensory and emotional experiences. However, the underlying mechanisms that mediate its different components remain unclear. Sphingosine-1-phosphate (S1P), a metabolite of sphingomyelin and a potent lipid mediator, initiates signaling...