Antimicrobial Potential of Strontium Hydroxide on Bacteria Associated with Peri-Implantitis

• Main Authors: Hatem Alshammari (Author), Jessica Neilands (Author), Gunnel Svensäter (Author), Andreas Stavropoulos (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Background</i>: Peri-implantitis due to infection of dental implants is a common complication that may cause significant patient morbidity. In this study, we investigated the antimicrobial potential of Sr(OH)₂ against different bacteria associated with peri-implantitis. <i>Methods</i>: The antimicrobial potential of five concentrations of Sr(OH)₂ (100, 10, 1, 0.1, and 0.01 mM) was assessed with agar diffusion test, minimal inhibitory concentration (MIC), and biofilm viability assays against six bacteria commonly associated with biomaterial infections: <i>Streptococcus mitis</i>, <i>Staphylococcus epidermidis</i>, <i>Aggregatibacter actinomycetemcomitans</i>, <i>Porphyromonas gingivalis</i>, <i>Escherichia coli</i>, and <i>Fusobacterium nucleatum</i>. <i>Results</i>: Zones of inhibition were only observed for, 0.01, 0.1, and 1 mM of Sr(OH)₂ tested against <i>P. gingivalis</i>, in the agar diffusion test. Growth inhibition in planktonic cultures was achieved at 10 mM for all species tested (<i>p</i> < 0.001). In biofilm viability assay, 10 and 100 mM Sr(OH)₂ showed potent bactericidal affect against <i>S. mitis</i>, <i>S. epidermidis</i>, <i>A. actinomycetemcomitans</i>, <i>E. coli</i>, and <i>P. gingivalis</i>. <i>Conclusions</i>: The findings of this study indicate that Sr(OH)₂ has antimicrobial properties against bacteria associated with peri-implantitis.

Item Description

10.3390/antibiotics10020150
2079-6382