Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate

• Egile Nagusiak: Randa Mohammed Zaki (Egilea), Munerah M. Alfadhel (Egilea), Manal A. Alossaimi (Egilea), Lara Ayman Elsawaf (Egilea), Vidya Devanathadesikan Seshadri (Egilea), Alanood S. Almurshedi (Egilea), Rehab Mohammad Yusif (Egilea), Mayada Said (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

This study aimed to formulate and statistically optimize glycerosomal formulations of Quetiapine fumarate (QTF) to increase its oral bioavailability and enhance its brain delivery. The study was designed using a Central composite rotatable design using Design-Expert^® software....