In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with Human Carbonic Anhydrase IX and XII Inhibition

• Main Authors: Giosuè Costa (Author), Annalisa Maruca (Author), Roberta Rocca (Author), Francesca Alessandra Ambrosio (Author), Emanuela Berrino (Author), Fabrizio Carta (Author), Francesco Mesiti (Author), Alessandro Salatino (Author), Delia Lanzillotta (Author), Francesco Trapasso (Author), Anna Artese (Author), Stefano Alcaro (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The tumor-associated isoenzymes <i>h</i>CA IX and <i>h</i>CA XII catalyze the hydration of carbon dioxide to bicarbonate and protons. These isoforms are highly overexpressed in many types of cancer, where they contribute to the acidification of the tumor environment, promotin...