In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with Human Carbonic Anhydrase IX and XII Inhibition

• Главные авторы: Giosuè Costa (Автор), Annalisa Maruca (Автор), Roberta Rocca (Автор), Francesca Alessandra Ambrosio (Автор), Emanuela Berrino (Автор), Fabrizio Carta (Автор), Francesco Mesiti (Автор), Alessandro Salatino (Автор), Delia Lanzillotta (Автор), Francesco Trapasso (Автор), Anna Artese (Автор), Stefano Alcaro (Автор), Claudiu T. Supuran (Автор)
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• Опубликовано: MDPI AG, 2020-08-01T00:00:00Z.
• Предметы: article
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The tumor-associated isoenzymes <i>h</i>CA IX and <i>h</i>CA XII catalyze the hydration of carbon dioxide to bicarbonate and protons. These isoforms are highly overexpressed in many types of cancer, where they contribute to the acidification of the tumor environment, promotin...