Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity

• Main Authors: Liujun Chen (Author), Lisha Li (Author), Donghong Cui (Author), Yiheng Huang (Author), Haibin Tong (Author), Haleh Zabihi (Author), Shuxia Wang (Author), Yadan Qi (Author), Ted Lakowski (Author), Lin Leng (Author), Suixin Liu (Author), Hong Wu (Author), Lawrence H. Young (Author), Richard Bucala (Author), Dake Qi (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. We investigate the role of cytokine, macrophage migration inhibitory factor (MIF) in regulating adipose HSL and adipocyte hypertrophy. Extracellular MIF downregulates HSL in an autocrine fashion, by ac...