Exacerbation of Darier Disease under Interferon-α-2a Therapy with Clinical Signs of Lichen Nitidus
Darier disease/dyskeratosis follicularis is a genodermatosis characterized by brown, oily keratotic papules and plaques in the seborrheic areas of the face and chest. Responsible for the disease are mutations in the ATP2A2 gene, encoding SERCA2, a calcium pump of the sarco-/endoplasmic reticulum. Me...
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Karger Publishers,
2016-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_4f46e4e46b384095b38a2cbb8fae0838 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ioannis Karagiannidis |e author |
| 700 | 1 | 0 | |a Martina Brunner |e author |
| 700 | 1 | 0 | |a Christos C. Zouboulis |e author |
| 245 | 0 | 0 | |a Exacerbation of Darier Disease under Interferon-α-2a Therapy with Clinical Signs of Lichen Nitidus |
| 260 | |b Karger Publishers, |c 2016-08-01T00:00:00Z. | ||
| 500 | |a 1662-6567 | ||
| 500 | |a 10.1159/000446693 | ||
| 520 | |a Darier disease/dyskeratosis follicularis is a genodermatosis characterized by brown, oily keratotic papules and plaques in the seborrheic areas of the face and chest. Responsible for the disease are mutations in the ATP2A2 gene, encoding SERCA2, a calcium pump of the sarco-/endoplasmic reticulum. Mechanical trauma, heat, humidity, ultraviolet B radiation, oral corticosteroids and lithium are known trigger factors of the disorder. We report on a 48-year-old German woman with a flare-up of Darier disease under interferon-α-2a (IFNα-2a) therapy with clinical signs of lichen nitidus. Due to the fulminant course of the eruption, we suspected IFNα as a possible trigger. To our knowledge there are no reports regarding exacerbation of Darier disease during IFNα therapy. Possible pathogenetic mechanisms are being discussed. | ||
| 546 | |a EN | ||
| 690 | |a Darier disease | ||
| 690 | |a Interferon-α | ||
| 690 | |a Lichen nitidus | ||
| 690 | |a Psoriasis vulgaris | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Case Reports in Dermatology, Vol 8, Iss 2, Pp 218-223 (2016) | |
| 787 | 0 | |n http://www.karger.com/Article/FullText/446693 | |
| 787 | 0 | |n https://doaj.org/toc/1662-6567 | |
| 856 | 4 | 1 | |u https://doaj.org/article/4f46e4e46b384095b38a2cbb8fae0838 |z Connect to this object online. |