The Role of Mcl-1 in S. aureus-Induced Cytoprotection of Infected Macrophages

• Main Authors: Joanna Koziel (Author), Katarzyna Kmiecik (Author), Daniela Chmiest (Author), Katarzyna Maresz (Author), Danuta Mizgalska (Author), Agnieszka Maciag-Gudowska (Author), Piotr Mydel (Author), Jan Potempa (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a facultative intracellular pathogen, Staphylococcus aureus invades macrophages and then promotes the cytoprotection of infected cells thus stabilizing safe niche for silent persistence. This process occurs through the upregulation of crucial antiapoptotic genes, in particular, myeloid cell leuke...