Novel phenylacetate derivatives isolated from the fungus Penicillium canescens
Two undescribed phenylacetate derivatives (compounds 1 and 2) with a known analog were isolated from a soil-derived fungus Penicillium canescens through the "one strain-many compounds" method. The new structures were assigned using extensive 1D and 2D NMR spectra, high-resolution electrosp...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
KeAi Communications Co., Ltd.,
2022-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Two undescribed phenylacetate derivatives (compounds 1 and 2) with a known analog were isolated from a soil-derived fungus Penicillium canescens through the "one strain-many compounds" method. The new structures were assigned using extensive 1D and 2D NMR spectra, high-resolution electrospray ionization mass spectrometry, and the comparison of coupling cleavages of known compounds, which are two pairs of racemic mixtures of aromatic polyketides with a terminal butan-2,3-diol group. In the bioassay, the biological screening signifies no cytotoxic activities against several human cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480) at a concentration of 40.0 µM. |
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| Item Description: | 2707-3688 10.1016/S2707-3688(23)00045-6 |