Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica.
BACKGROUND: Entamoeba histolytica is responsible for causing amoebiasis. Polyamine biosynthesis pathway enzymes are potential drug targets in parasitic protozoan diseases. The first and rate-limiting step of this pathway is catalyzed by ornithine decarboxylase (ODC). ODC enzyme functions as an oblig...
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Main Authors: | Preeti (Author), Satya Tapas (Author), Pravindra Kumar (Author), Rentala Madhubala (Author), Shailly Tomar (Author) |
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Format: | Book |
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Public Library of Science (PLoS),
2012-01-01T00:00:00Z.
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