BRD4 inhibitor reduces exhaustion and blocks terminal differentiation in CAR-T cells by modulating BATF and EGR1
Abstract Background Exhaustion is a key factor that influences the efficacy of chimeric antigen receptor T (CAR-T) cells. Our previous study demonstrated that a bromodomain protein 4 (BRD4) inhibitor can revise the phenotype and function of exhausted T cells from leukemia patients. This study aims t...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
BMC,
2024-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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