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Acute Myeloid Leukemia: analysis of epidemiological profile and survival rate

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Objective: To describe the epidemiological profile and the survival rate of patients with acute myeloid leukemia (AML) in a state reference pediatric hospital. Method: Clinical‐epidemiological, observational, retrospective, descriptive study. The study included new cases of patients with AML, diagno...

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Main Authors: Mariana Cardoso de Lima (Author), Denise Bousfield da Silva (Author), Ana Paula Ferreira Freund (Author), Juliana Shmitz Dacoregio (Author), Tatiana El Jaick Bonifácio Costa (Author), Imaruí Costa (Author), Daniel Faraco (Author), Maurício Laerte Silva (Author)
Format: Book
Published: Brazilian Society of Pediatrics, 2016-05-01T00:00:00Z.
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Summary:Objective: To describe the epidemiological profile and the survival rate of patients with acute myeloid leukemia (AML) in a state reference pediatric hospital. Method: Clinical‐epidemiological, observational, retrospective, descriptive study. The study included new cases of patients with AML, diagnosed between 2004 and 2012, younger than 15 years. Results: Of the 51 patients studied, 84% were white; 45% were females and 55%, males. Regarding age, 8% were younger than 1 year, 47% were aged between 1 and 10 years, and 45% were older than 10 years. The main signs/symptoms were fever (41.1%), asthenia/lack of appetite (35.2%), and hemorrhagic manifestations (27.4%). The most affected extra‐medullary site was the central nervous system (14%). In 47% of patients, the white blood cell (WBC) count was below 10,000/mm3 at diagnosis. The minimal residual disease (MRD) was less than 0.1%, on the 15th day of treatment in 16% of the sample. Medullary relapse occurred in 14% of cases. When comparing the bone marrow MRD with the vital status, it was observed that 71.42% of the patients with type M3 AML were alive, as were 54.05% of those with non‐M3 AML. The death rate was 43% and the main proximate cause was septic shock (63.6%). Conclusions: In this study, the majority of patients were male, white, and older than 1 year. Most patients with WBC count < 10,000/mm3 at diagnosis lived. Overall survival was higher in patients with MRD < 0.1%. The prognosis was better in patients with AML‐M3.
Item Description:2255-5536
10.1016/j.jpedp.2016.02.003

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