Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug-drug-gene interaction network

• Main Authors: Denise Feick (Author), Simeon Rüdesheim (Author), Fatima Zahra Marok (Author), Dominik Selzer (Author), Helena Leonie Hanae Loer (Author), Donato Teutonico (Author), Sebastian Frechen (Author), Maaike van derLee (Author), Dirk Jan A. R. Moes (Author), Jesse J. Swen (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug-drug interaction (DDI) studies. However, as quinidine is also a substrate of CYP3A4 and P‐gp, it is susceptible to DDIs invol...