Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System
PTEN expression is lost in many cancers, and even small changes in PTEN activity affect susceptibility and prognosis in a range of highly aggressive malignancies, such as melanoma and triple-negative breast cancer (TNBC). Loss of PTEN expression occurs via multiple mechanisms, including mutation, tr...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2019-03-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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