GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis

• Main Authors: Jiawei Zhang (Author), Xianzheng Zhang (Author), Mingdian Lu (Author), Yan Chang (Author), Qingtong Wang (Author), Jiajie Tu (Author), Huaxun Wu (Author), Chun Wang (Author), Zhongyang Hong (Author), Maoming Xiong (Author), Lihua Song (Author), Wei Wei (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage polarization. However, the role of GRK2 in the patho...