Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats
Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This s...
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| Main Authors: | , , , |
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| Format: | Book |
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Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya,
2023-02-01T00:00:00Z.
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| Summary: | Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study was aimed to investigate SNEDDS of I. reptans acute toxicity on female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into two groups, control and treatment group, with 3 animals for each group were used per step. There are no animals that died after were given SNEDDS of I. reptans leaves extract at a dose of 2000 mg/kg. No toxic effect was detected at clinical examination and histopathology of the organ. SNEDDS of I. reptans leaves extract has an LD50 cut-off value of 5000 mg/kg. |
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| Item Description: | 10.33084/bjop.v6i1.2099 2621-4814 |