Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway

• Main Authors: Li Li (Author), Shihua Deng (Author), Mingquan Liu (Author), Min Yang (Author), Jin Li (Author), Teng Liu (Author), Ting Zhang (Author), Yangyang Zhao (Author), Miao He (Author), Dongming Wu (Author), Ying Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease characterized by demyelination and neurodegeneration, for which traditional treatment offers limited relief. Microglial/macrophage modulation plays a critical role in the pathogenesis of MS. Oxygen free radical accumulation can ind...