Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway

• Main Authors: Zhiwei Zhang (Author), Xiaowei Zhang (Author), Lei Meng (Author), Mengqi Gong (Author), Jian Li (Author), Wen Shi (Author), Jiuchun Qiu (Author), Yajuan Yang (Author), Jianping Zhao (Author), Ya Suo (Author), Xue Liang (Author), Xinghua Wang (Author), Gary Tse (Author), Ning Jiang (Author), Guangping Li (Author), Yungang Zhao (Author), Tong Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Oxidative stress contributes to adverse atrial remodeling in diabetes mellitus. This remodeling can be prevented by the PPAR-γ agonist pioglitazone via its antioxidant and anti-inflammatory effects. In this study, we examined the molecular mechanisms underlying the protective effects of...