Meta-analysis of associations between <it>TCF7L2</it> polymorphisms and risk of type 2 diabetes mellitus in the Chinese population

• Main Authors: Wang Jinjin (Author), Hu Fulan (Author), Feng Tianping (Author), Zhao Jingzhi (Author), Yin Lei (Author), Li Linlin (Author), Wang Yan (Author), Wang Qian (Author), Hu Dongsheng (Author)
• Format: Book
• Published: BMC, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.1186/1471-2350-14-8; 1471-2350
• Keywords: Type 2 diabetes; T2DM; TCF7L2; SNPs; Meta-analysis; Internal medicine; RC31-1245; Genetics; QH426-470
• Source: BMC Medical Genetics, Vol 14, Iss 1, p 8 (2013)

<p>Abstract</p> <p>Background</p> <p>Associations between transcription factor 7-like 2 (<it>TCF7L2</it>) polymorphisms and type 2 diabetes mellitus (T2DM) have been evaluated extensively in multiple ethnic groups. <it>TCF7L2</it> has emerged as the strongest T2DM susceptibility gene in Europeans, but the findings have been inconsistent in the Chinese population. The purpose of this meta-analysis was to evaluate the associations between <it>TCF7L2</it> single nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population.</p> <p>Methods</p> <p>We performed searches in the PubMed, EMBASE, Cochrane, and Chinese databases (CNKI, CQVIP and Wanfang databases) for literature published from January 2007 to February 2012. We reviewed all relevant articles on <it>TCF7L2</it> polymorphisms and susceptibility to T2DM in the Chinese population written in English and Chinese. Two reviewers extracted data independently using a standardized protocol, and any discrepancies were adjudicated by a third reviewer. Fixed-effects and random-effects meta-analyses were performed to pool the odds ratios (ORs). Publication bias and heterogeneity were examined.</p> <p>Results</p> <p>A total of 21 articles were confirmed to be eligible for and included in this meta-analysis: 7 (with 3942 cases and 3502 controls) concerning rs11196218 (IVS−/+4G>A), 8 (with 3377 cases and 2975 controls) concerning rs290487 (IVS3−/+C>T), and 14 (with 7902 cases and 7436 controls) concerning rs7903146 (IVS3−/+C>T). Overall, the results showed a significant association between rs7903146 and T2DM risk. The pooled ORs were 1.54 for the comparison of T and C alleles (95% CI [confidence interval]: 1.37-1.74, <it>p</it> = 1.47 × 10^-12, <it>I</it>² = 25.20%) and 1.56 for TC heterozygotes and CC homozygotes (95% CI : 1.38-1.76, <it>p</it> = 8.25 × 10^-9, <it>I</it>² = 21.00%). The rs11196218(IVS4G>A) and rs290487 (IVS3C>T) SNPs were not associated with T2DM risk.</p> <p>Conclusions</p> <p>The rs7903146 SNP of the <it>TCF7L2</it> gene is associated with increased susceptibility to T2DM in the Chinese population as a whole as well as northern Chinese and southern Chinese as subgroups.</p>