Evaluation mutagenic and antimutagenic activity of Chamomilla recutita(L.) Rauschert in Allium cepatest/Avaliação da atividade mutagênica e antimutagênicadaChamomilla recutita (L.)Rauschert,em teste deAlliumcepa

• Main Authors: Cibele Merched Gallo (Author), José Dailson Silva de Oliveira (Author), Everton Ferreira dos Santos (Author), Renato Vieira de Carvalho Filho (Author), Wyslane Larissa Almeida Santos Rocha e Silva (Author), Maria da Graça Martino-Roth (Author)
• Format: Book
• Published: Universidade Estadual de Alagoas, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The use of Chamomilla recutita as a tranquilizing, anti-inflammatory, and analgesic tea is based on the empirical knowledge of medicinal plants. This work aims at assessing the mutagenic and antimutagenic potential -by means of the Allium cepatest -of an infusion of dry chamomile leaves. Eleven trials were conducted, with four replicates each, as such: T1 -negative control; T2 -paracetamol, 800mg L-1(positive control); T3 -chamomile in the usual dose, 12g L-1; T4 -60g L-1of chamomile; T5 -120g L-1of chamomile;T6 -paracetamol 800mg L-1and chamomile12g L-1; T7 -paracetamol 800mg L-1and chamomile 60g L-1; T8 -paracetamol 800mg L-1and chamomile120g L-1; T9 -paracetamol 800mg L-1and, 24 hours later, chamomile 12g L-1; T10 -paracetamol 800mg L-1and, 24 hours later, chamomile 60g L-1; T11 -paracetamol 800mg L-1and,24 hours later, chamomile 120g L-1.It was found that both the 12g L-1infusion and the stronger ones significantly reduced the mitotic index. In regard to mitotic anomalies, only T11 was significantly increased relative to T1 (p=0.012). All trials increased the frequency of interphase anomalies in a significant way (p<0.018),thus also showing an increase in the total of anomalies (p<0.018). Such results show that chamomile had a cytotoxic effect and protects against the positive control, on meristematic cells of Allium cepa.

Item Description

10.17648/diversitas-journal-v5i3-985
2525-5215