Different formulations of peracetic acid: effects on smear layer removal, dentine erosion, cytotoxicity and antibiofilm activity

Abstract Objective: To assess the effects of different peracetic acid (PAA) formulations on smear layer (SL) removal, dentine erosion, cytotoxicity, and antibiofilm activity. Methodology: SL removal and dentine erosion were assessed using 90 premolars, distributed into six groups, according to final...

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Main Authors: Kennia Scapin Viola (Author), Hernán Coaguila-Llerena (Author), Elisandra Marcia Rodrigues (Author), Cíntia Silva Santos (Author), Gisselle Moraima Chávez-Andrade (Author), Miriam Graziele Magro (Author), Mario Tanomaru-Filho (Author), Juliane Maria Guerreiro-Tanomaru (Author), Gisele Faria (Author)
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Published: University of São Paulo, 2022-03-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_511b3dc0b9c641a6b50d963ff8bf9ddc
042 |a dc 
100 1 0 |a Kennia Scapin Viola  |e author 
700 1 0 |a Hernán Coaguila-Llerena  |e author 
700 1 0 |a Elisandra Marcia Rodrigues  |e author 
700 1 0 |a Cíntia Silva Santos  |e author 
700 1 0 |a Gisselle Moraima Chávez-Andrade  |e author 
700 1 0 |a Miriam Graziele Magro  |e author 
700 1 0 |a Mario Tanomaru-Filho  |e author 
700 1 0 |a Juliane Maria Guerreiro-Tanomaru  |e author 
700 1 0 |a Gisele Faria  |e author 
245 0 0 |a Different formulations of peracetic acid: effects on smear layer removal, dentine erosion, cytotoxicity and antibiofilm activity 
260 |b University of São Paulo,   |c 2022-03-01T00:00:00Z. 
500 |a 1678-7765 
500 |a 10.1590/1678-7757-2021-0575 
520 |a Abstract Objective: To assess the effects of different peracetic acid (PAA) formulations on smear layer (SL) removal, dentine erosion, cytotoxicity, and antibiofilm activity. Methodology: SL removal and dentine erosion were assessed using 90 premolars, distributed into six groups, according to final irrigation: PAA formulations (1% Sigma, 1% Bacterend OX, 1% Arposept, and 0.09-0.15% Anioxyde), 17% ethylenediaminetetraacetic acid (EDTA), and water (control). Cytotoxicity was assessed by methyl-thiazol-tetrazolium (MTT) and neutral red assays. Antibacterial and antibiofilm effectiveness was evaluated against Enterococcus faecalis. For cytotoxicity and antibiofilm activity assessment, the 2.5% NaOCl was also included. Results: EDTA, Sigma, and Bacterend OX removed more SL than Arposept, Anioxyde, and water (p<0.05). EDTA caused more severe dentine erosion than Sigma and Bacterend OX (p<0.05). Sigma and Bacterend OX had higher cytotoxicity than the other solutions (p<0.05). NaOCl, Bacterend OX, Sigma, and Anioxyde significantly reduced E. faecalis colony-forming units (CFU) (p<0.05). The 2.5% NaOCl solution promoted greater biofilm biomass reduction (p<0.05) than the other solutions. All PAA formulations promoted greater biomass reduction than 17% EDTA (p<0.05). Conclusions: Although Sigma and Bacterend OX had higher cytotoxicity, they had a SL removal capability similar to that of EDTA, were as effective as NaOCl against E. faecalis biofilm, and promoted less dentine erosion than EDTA. Arposept and Anioxyde failed to remove the SL, had lower cytotoxicity, and showed less bacterial activity than NaOCl. 
546 |a EN 
690 |a Cell viability 
690 |a Dentin 
690 |a Enterococcus faecalis 
690 |a Peracetic acid 
690 |a Smear layer 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Journal of Applied Oral Science, Vol 30 (2022) 
787 0 |n http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572022000100414&lng=en&tlng=en 
787 0 |n http://www.scielo.br/pdf/jaos/v30/1678-7765-jaos-30-e20210575.pdf 
787 0 |n https://doaj.org/toc/1678-7765 
856 4 1 |u https://doaj.org/article/511b3dc0b9c641a6b50d963ff8bf9ddc  |z Connect to this object online.