Sex-dependent anti-stress effect of an α5 subunit containing GABAA receptor positive allosteric modulator

• Ngā kaituhi matua: Sean C. Piantadosi (Author), Beverly J French (Author), Michael M Poe (Author), Tamara Timić (Author), Bojan Marković (Author), Mohan Pabba (Author), Marianne Seney (Author), Hyunjung Oh (Author), Beverley Anne Orser (Author), Miroslav M Savic (Author), James M Cook (Author), Etienne Sibille (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Rationale: Current first-line treatments for stress-related disorders such as Major Depressive Disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission rates. Recent research has implicated the GABAergic system in the pathophysio...