Simple change in logistic procedure improves response rate to QOL assessment: a report from the Japan Children's Cancer Group
Abstract Background Reducing non-completion of quality-of-life assessment in clinical trials is an important challenge in obtaining accurate data and unbiased interpretation of patients' quality-of-life for each regimen. We evaluated the effect of changing our questionnaire distribution procedu...
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| Main Authors: | , , , , , |
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| Format: | Book |
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SpringerOpen,
2020-06-01T00:00:00Z.
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| Summary: | Abstract Background Reducing non-completion of quality-of-life assessment in clinical trials is an important challenge in obtaining accurate data and unbiased interpretation of patients' quality-of-life for each regimen. We evaluated the effect of changing our questionnaire distribution procedure in a multicenter phase II/III trial on the response rate to a quality-of-life questionnaire. Methods In the trial, we distributed 1767 questionnaires and 1045 were returned. We adopted a regression discontinuing design and estimated the change in response rate between pre-intervention (quality-of-life questionnaires were sent to each center soon after patient registration) and post-intervention (a set of tailored questionnaires was sent just before the first quality-of-life assessment). Results The post-intervention response rate was higher (odds ratio = 1.62) than the pre-intervention response rate. Conclusions A simple logistic intervention reduced the non-completion of QOL assessment in this case, suggesting that a simple change can contribute to improving clinical trial accomplishment. |
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| Item Description: | 10.1186/s41687-020-00214-9 2509-8020 |