LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis

• Main Authors: Yasuka Matsunaga (Author), Yusuke Nakatsu (Author), Toshiaki Fukushima (Author), Hirofumi Okubo (Author), Misaki Iwashita (Author), Hideyuki Sakoda (Author), Midori Fujishiro (Author), Takeshi Yamamotoya (Author), Akifumi Kushiyama (Author), Shin-ichiro Takahashi (Author), Yoshihiro Tsuchiya (Author), Hideaki Kamata (Author), Fuminori Tokunaga (Author), Kazuhiro Iwai (Author), Tomoichiro Asano (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonalcoholic steatohepatitis (NASH) is a disorder characterized by hepatic lipid accumulation followed by the inflammation-induced death of hepatocytes and fibrosis. In this process, oxidative stress contributes to the induction of several inflammatory cytokines including TNF-α and　IL-1β in macropha...