Variables associated with malondialdehyde level in thalassemia major patients
BackgmundThalassemia is the most cormnon hereditary haemolytic anaemia in the world, including in Indonesia. The main treatment for thalassemia is regular transfusions, but these are knO\vn to cause iron overload. Moreover, iron overload in jJthalassemia patients generates oxygen free radicals and...
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Indonesian Pediatric Society Publishing House,
2012-06-01T00:00:00Z.
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| Summary: | BackgmundThalassemia is the most cormnon hereditary haemolytic anaemia in the world, including in Indonesia. The main treatment for thalassemia is regular transfusions, but these are knO\vn to cause iron overload. Moreover, iron overload in jJthalassemia patients generates oxygen free radicals and peroxidative lipid injury. Ferritin serum concentration is used as indirect measurement of iron overload. Malondialdehyde (MDA), a terminal compound oflipid peroxidation, is used as an index of oxidative stress status. Objective To assess the correlation between iron overload (serum ferritin level) and MDA as a marker of oxidative stress in thalassemia major patients. Methods This c rosssectional study was conducted at Cipto Mangunkusumo Hospital, Jakarta, from MayJune 2009. Subjects were thalassemia major patients (homozygous jJthalassemia or jJthalassemia;HbE) who received regular blood transfusions, iron chelation, and vitamin E as an antioxidant. Data was collected by his torytaking, physical examination, medical records, and questionnaires. Blocd specimens were dra\Vll from the thalassemia major subjects before transfusion and examined for serum ferritin and MDA levels. Results Fiftyfive subjects Mth thalassemia major (34 homozygous jJthalassemia and 21 jJthalassemia;HbE) were included in our study. Mean serum ferritin level was 3693.2 (SD 21423),ug/L and me811 MDA level was 0.641 (SD 0.283) nmolimL. No cor relation was found between serum ferritin and MDA levels in thalassemia major subjects (r=0.147, P=0.285). As additional results, this study also showed no correlation between MDA to reguler vitamin E consumption (r=0.277, P=0.028) as well as MDA and nutritional status (F0371, P0.()J4). Conclusion There was no cor relation between serum ferritin level and plasma MDA level in thalassemia major subjects, no cor relations between MDA and regular vitamin E consumption, as well as MDA and nutritional status. [paediatr Indones. 2012;52:125,31]. |
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| Item Description: | 0030-9311 2338-476X 10.14238/pi52.3.2012.125-31 |