Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding ps...

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Main Authors: Javad Sharifi-Rad (Author), Senem Kamiloglu (Author), Balakyz Yeskaliyeva (Author), Ahmet Beyatli (Author), Mary Angelia Alfred (Author), Bahare Salehi (Author), Daniela Calina (Author), Anca Oana Docea (Author), Muhammad Imran (Author), Nanjangud Venaktesh Anil Kumar (Author), Maria Eugenia Romero-Román (Author), Alfred Maroyi (Author), Miquel Martorell (Author)
Format: Book
Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Javad Sharifi-Rad  |e author 
700 1 0 |a Senem Kamiloglu  |e author 
700 1 0 |a Balakyz Yeskaliyeva  |e author 
700 1 0 |a Ahmet Beyatli  |e author 
700 1 0 |a Mary Angelia Alfred  |e author 
700 1 0 |a Bahare Salehi  |e author 
700 1 0 |a Daniela Calina  |e author 
700 1 0 |a Anca Oana Docea  |e author 
700 1 0 |a Muhammad Imran  |e author 
700 1 0 |a Nanjangud Venaktesh Anil Kumar  |e author 
700 1 0 |a Maria Eugenia Romero-Román  |e author 
700 1 0 |a Alfred Maroyi  |e author 
700 1 0 |a Miquel Martorell  |e author 
700 1 0 |a Miquel Martorell  |e author 
245 0 0 |a Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action 
260 |b Frontiers Media S.A.,   |c 2020-10-01T00:00:00Z. 
500 |a 1663-9812 
500 |a 10.3389/fphar.2020.571459 
520 |a Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: "Psoralidin" or "therapeutic effects" or "biological activity" or "Cullen corylifolium" in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases. 
546 |a EN 
690 |a Psoralea corylifolia 
690 |a herbal medicine 
690 |a psoralidin 
690 |a bioavailability 
690 |a biological properties 
690 |a molecular mechanisms 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pharmacology, Vol 11 (2020) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fphar.2020.571459/full 
787 0 |n https://doaj.org/toc/1663-9812 
856 4 1 |u https://doaj.org/article/51aaa81a1b4c49afa7a5bf2e75f89d8d  |z Connect to this object online.