The Effect of Aquae Extract of Aloe vera on Synaptophysin Expression after Spinal Cord Compression in Adult Rats

• Main Authors: M Heshmati (Author), MR Jalali Nadoushan (Author), E Entezari (Author), Z Khodashenas (Author)
• Format: Book
• Published: Institue of Medicinal Plants, ACECR, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2717-204X; 2717-2058
• Keywords: keywords: aloe vera; spinal cord injury; synaptophysin; Therapeutics. Pharmacology; RM1-950; Toxicology. Poisons; RA1190-1270
• Source: Journal of Medicinal Plants, Vol 12, Iss 46, Pp 38-49 (2013)

Background: Spinal cord compression is one of causes for disability. Nowadaysto minimize these complication is a goal. Objective: The effect of aquae extract of Aloe vera on motoneuron death and chemical neurotransmitter for cell signaling in paralysed rats. Methods: We used 32 female rats from Razi institute. They were randomized divided to 4 groups: 1- control 2- treated with Aloe vera 3- treated with Aloe vera + spinal cord compression by clips aneurysm 4- control+spinal cord compression by clips aneurysm. Perituneal injection continued for 4 weeks (every day). We used 2.5 mg/kg aquae extract of Aloe vera. Results: Compression hascaused, motoneuron in ventral horn decreases with cavitation. Insecond group these changes are less (p≤ 0.05). Aloe vera increasessynaptophysin in complete and partial model (p≤ 0.05). Conclusion: For the first time Aloe vera has studied for synaptic reaction. It seems the number and percentage of motoneurons increased, as the same as synaptophysin in complete and partial model.