FGF8-FGFR1 signaling regulates human GnRH neuron differentiation in a time- and dose-dependent manner

• Main Authors: Venkatram Yellapragada (Author), Nazli Eskici (Author), Yafei Wang (Author), Shrinidhi Madhusudan (Author), Kirsi Vaaralahti (Author), Timo Tuuri (Author), Taneli Raivio (Author)
• Format: Book
• Published: The Company of Biologists, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing hormone-expressing neurons (GnRH neurons). We hypothesized that FGF8 regulates differentiation of human GnRH neurons in a time- and do...