Supramolecular approaches for insulin stabilization without prolonged duration of action

• Main Authors: Rolande Meudom (Author), Yanxian Zhang (Author), Michael A. VandenBerg (Author), Lei Zou (Author), Yi Wolf Zhang (Author), Matthew J. Webber (Author), Danny Hung-Chieh Chou (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aggregation represents a significant challenge for the long-term formulation stability of insulin therapeutics. The supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol (CB[7]‒PEG) has been shown to stabilize insulin formulations by reducing aggregation pro...