Acetazolamide and human carbonic anhydrases: retrospect, review and discussion of an intimate relationship
AbstractAcetazolamide (AZM) is a strong pharmacological sulphonamide-type (R-SO2-NH2, pKa 7.2) inhibitor of the activity of several carbonic anhydrase (CA) isoforms, notably of renal CA II (Ki, 12 nM) and CA IV (Ki, 74 nM). AZM is clinically used for about eighty years in various diseases including...
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Taylor & Francis Group,
2024-12-01T00:00:00Z.
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