Dihydropyrimidine Dehydrogenase Levels in Colorectal Cancer Cells Treated with a Combination of Heat Shock Protein 90 Inhibitor and Oxaliplatin or Capecitabine

• Main Authors: Mahshid Mohammadian (Author), Shima Zeynali-Moghaddam (Author), Mohammad Hassan Khadem Ansari (Author), Yousef Rasmi (Author), Anahita Fathi Azarbayjani (Author), Fatemeh Kheradmand (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme in the catabolism of fluoropyrimidine drugs including capecitabine. A recent report has suggested that oxaliplatin chemotherapy is associated with elevated DPD levels and chemoresistance pattern. As a newly developed chemotherape...