Evaluation of microsatellite instability in routine examinations of surgical samples

• Autores principales: Pawel Wlaszczuk (Autor), Aleksandra Kuzbinska (Autor), Zuzanna Dobrosz (Autor), Piotr Palen (Autor), Krzysztof Pawlicki (Autor)
• Formato: Libro
• Publicado: Wolters Kluwer Medknow Publications, 2022-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Context: Approximately 20%-30% of colon cancer cases have a hereditary basis. The genetic defect may involve mismatch repair (MMR) genes, which results in microsatellite instability (MSI). MMR-deficient colorectal cancer may occur due to germline mutation (Lynch syndrome) or be a sporadic one. A tum...