Evaluation of microsatellite instability in routine examinations of surgical samples

• Main Authors: Pawel Wlaszczuk (Author), Aleksandra Kuzbinska (Author), Zuzanna Dobrosz (Author), Piotr Palen (Author), Krzysztof Pawlicki (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: Approximately 20%-30% of colon cancer cases have a hereditary basis. The genetic defect may involve mismatch repair (MMR) genes, which results in microsatellite instability (MSI). MMR-deficient colorectal cancer may occur due to germline mutation (Lynch syndrome) or be a sporadic one. A tum...