Association between Iron Status and Lipid Peroxidation in Obese and Non-Obese Women

• Main Authors: F Amirkhizi (Author), F Siassi (Author), S Minaie (Author), M Djalali (Author), A Rahimi (Author), M Chamari (Author)
• Format: Book
• Published: Tehran University of Medical Sciences, 2008-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

"nBackground: Obesity is associated with increased lipid peroxidation. It has also been suggested that risk of lipid peroxida­tion increases with increasing body iron stores. The aim of this study was to examine the association of body iron status with the concentration of plasma malondialdehyde (P-MDA) as a marker of lipid peroxidation in obese and non-obese women."nMethods: In a case control study we investigated iron status by plasma ferritin, iron and total iron binding capacity (TIBC) meas­urements and lipid peroxidation by plasma malondialdehyde (MDA) levels measurements in 25 obese women and 25 non-obese women matched for age."nResults: Plasma ferritin levels were significantly higher in obese groups compared with control groups (P< 0.001). Plasma TIBC levels were not different in both groups and plasma iron levels were significantly higher in obese groups (P< 0.05). In obese groups, plasma MDA levels were significantly higher when compared with control groups (P< 0.001). There were posi­tive correlation between body mass index and plasma MDA levels (r= 0.75, P< 0.0001). Plasma MDA levels were posi­tively correlated with plasma iron levels (r= 0.26, P= 0.001) and plasma ferritin levels (r= 0.39, P< 0.0001) but not with TIBC levels."nConclusion: These findings suggest that obese menstruating women are at low risk of depleting iron stores and hence, increas­ing body iron elevates the CHD risk by promoting the lipid peroxidation. Therefore, iron fortification programs might be undesirable for such subjects. 

Item Description

2251-6085