Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

• Hauptverfasser: Philip E. Lapinski (VerfasserIn), Melissa F. Meyer (VerfasserIn), Gen-Sheng Feng (VerfasserIn), Nobuhiro Kamiya (VerfasserIn), Philip D. King (VerfasserIn)
• Format: Buch
• Veröffentlicht: The Company of Biologists, 2013-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

SUMMARY In mice, induced global disruption of the Ptpn11 gene, which encodes the SHP-2 tyrosine phosphatase, results in severe skeletal abnormalities. To understand the extent to which skeletal abnormalities can be attributed to perturbation of SHP-2 function in bone-forming osteoblasts and chondroc...