Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

• Prif Awduron: Philip E. Lapinski (Awdur), Melissa F. Meyer (Awdur), Gen-Sheng Feng (Awdur), Nobuhiro Kamiya (Awdur), Philip D. King (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: The Company of Biologists, 2013-11-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

SUMMARY In mice, induced global disruption of the Ptpn11 gene, which encodes the SHP-2 tyrosine phosphatase, results in severe skeletal abnormalities. To understand the extent to which skeletal abnormalities can be attributed to perturbation of SHP-2 function in bone-forming osteoblasts and chondroc...