Lack of AKT in adipocytes causes severe lipodystrophy

• Prif Awduron: Abigail L. Shearin (Awdur), Bobby R. Monks (Awdur), Patrick Seale (Awdur), Morris J. Birnbaum (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2016-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Objective: Adipose depot mass is tightly regulated to maintain energy homeostasis. AKT is a critical kinase in the insulin-signaling cascade that is required for the process of adipogenesis in vitro. However, the role of AKT in the maintenance and/or function of mature adipocytes in vivo had not bee...