Targeting Wnt/β-Catenin Pathway for Drug Therapy
The Wnt/β-catenin signaling pathway, including canonical or noncanonical pathway, is a highly conserved pathway which can regulate cell proliferation, migration, differentiation, and apoptosis. The Wnt pathway has been shown to undergo aberrant activation in various cancers, particularly colorectal...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
Elsevier,
2020-12-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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| Summary: | The Wnt/β-catenin signaling pathway, including canonical or noncanonical pathway, is a highly conserved pathway which can regulate cell proliferation, migration, differentiation, and apoptosis. The Wnt pathway has been shown to undergo aberrant activation in various cancers, particularly colorectal cancer. Wnt-targeted therapy attracted attention in a significant area of developmental therapeutics. Extensive efforts have been made to develop small-molecule drugs to inhibit the pathway for the treatment of various diseases. These small molecules disrupt protein-protein interactions in key parts of the pathway. Here, we review current indications for drug therapy and some problems in the treatment process that may be addressed in future investigations. |
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| Item Description: | 2590-0986 10.1016/j.medidd.2020.100066 |