Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function

• Main Authors: Maria J. Gonzalez-Rellan (Author), Tamara Parracho (Author), Violeta Heras (Author), Amaia Rodriguez (Author), Marcos F. Fondevila (Author), Eva Novoa (Author), Natalia Lima (Author), Marta Varela-Rey (Author), Ana Senra (Author), Maria D.P. Chantada-Vazquez (Author), Cristina Ameneiro (Author), Ganeko Bernardo (Author), David Fernandez-Ramos (Author), Fernando Lopitz-Otsoa (Author), Jon Bilbao (Author), Diana Guallar (Author), Miguel Fidalgo (Author), Susana Bravo (Author), Carlos Dieguez (Author), Maria L. Martinez-Chantar (Author), Oscar Millet (Author), Jose M. Mato (Author), Markus Schwaninger (Author), Vincent Prevot (Author), Javier Crespo (Author), Gema Frühbeck (Author), Paula Iruzubieta (Author), Ruben Nogueiras (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: O-GlcNAcylation is a post-translational modification that directly couples the processes of nutrient sensing, metabolism, and signal transduction, affecting protein function and localization, since the O-linked N-acetylglucosamine moiety comes directly from the metabolism of glucose, lipi...