Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs.
Buruli ulcer (BU) is a progressive disease of subcutaneous tissues caused by Mycobacterium ulcerans. The pathology of BU lesions is associated with the local production of a diffusible substance, mycolactone, with cytocidal and immunosuppressive properties. The defective inflammatory responses in BU...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
Public Library of Science (PLoS),
2008-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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